10 ALARMING Signs of Chronic Kidney Disease (Are You at Risk?)

up in your blood. This can lead to constant fatigue , low energy, and even trouble concentrating.

Why it matters: This could signal anemia—a common complication of CKD.

2. Swelling in Ankles, Feet, or Hands
Kidneys helps regulate salt and fluid in the body. Impaired kidney function can cause fluid retention , leading to swelling (edema), especially in the legs, ankles, and hands .

Don’t ignore: Persistent puffiness may be a red flag.

3. Changes in Urination
Changes in frequency, color, or consistency of urine are major indicators of kidney issues. Watch out

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