generally well tolerated, but rare cases of severe muscle breakdown (rhabdomyolysis) can release substances that overload the kidneys. The overall risk is low, but attention to muscle pain with high doses is important.
#5 Lithium (Used for Bipolar Disorder)
Long-term use requires continuous kidney monitoring, as it can affect urine concentration and contribute to gradual impairment over the years.
#4 Some Antivirals — Tenofovir, High-Dose Acyclovir
Essential in the treatment of certain viral infections, they can stress the tubules in some cases, leading to electrolyte imbalances. Newer options and frequent monitoring
