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How the Kidneys Handle Medication
The kidneys filter about 200 liters of blood per day. Many medications are metabolized or eliminated by them. When used improperly, in high doses, for long periods, or in situations of dehydration, they can overload this function.
Some medications reduce renal blood flow, while others cause inflammation or direct toxicity to the cells. The danger increases in people over 60, diabetics, those with high blood pressure, or those with pre-existing kidney disease.