therapy, allergy controls, reflux lifestyle changes).
What the Science Still Can’t Tell Us
Causality: We don’t know whether these drugs directly contribute to dementia biology or simply track with conditions (depression, insomnia, bladder dysfunction) that themselves raise risk. Rigorous randomized trials are difficult and rare.
Who’s most susceptible: Genetics, vascular risk, sleep disorders, and lifestyle likely modify vulnerability.
PPIs: Evidence remains inconclusive; decisions should balance proven benefits (e.g., bleeding prevention in high-risk patients) against potential long-term harms and use the shortest effective course.
A Holistic Brain-Health Plan (That Helps
