simply by whether it is natural or synthetic.
## When Ibuprofen Needs Extra Caution
Ibuprofen can be effective, but regular or high-dose use can increase risks such as:
* Stomach irritation or ulcers
* Gastrointestinal bleeding
* Kidney problems
* Fluid retention
* Higher blood pressure
* Cardiovascular complications in some people
Risk tends to be greater in older adults and people with kidney disease, cardiovascular disease, or a history of ulcers.
## Who Should Be Especially Careful With NSAIDs?
Extra caution is warranted in people with:
* Previous stomach ulcers
* Kidney disease
* Heart failure
* High blood pressure
* Cardiovascular
